Dr LIM Chwee Teck (林水德)

Provost's Chair Professor
Department of Biomedical Engineering & Department of Mechanical Engineering
Principal Investigator, Mechanobiology Institute
Faculty Fellow, Singapore-MIT Alliance for Research & Technology (SMART)
National University of Singapore
9 Engineering Drive 1
Singapore 117575
Contact: +65-6516-7801

Homepage: http://www.bioeng.nus.edu.sg/people/pi/lmteck/default.html

Professor Lim is a Provost’s Chair Professor at the Department of Biomedical Engineering, a Principal Investigator at the Mechanobiology Institute as well as a Faculty Fellow of the Singapore-MIT Alliance for Research & Technology. He is founding member of the Department of Biomedical Engineering, the university’s Nanoscience and Nanotechnology Initiative as well as the university’s Centre for Advanced 2D Materials. Prof Lim’s research interest are interdisciplinary and they include the mechanobiology of human diseases such as malaria and cancer, development of microfluidic technologies for disease detection, diagnosis and therapy and 2D materials for biomedical applications.

He has authored more than 320 peer-reviewed papers (including 49 invited/review articles), 28 book chapters and delivered more than 300 plenary/keynote/invited talks. He is an elected Fellow of the American Institute for Medical and Biological Engineering, International Academy of Medical and Biological Engineering as well as the Academy of Engineering, Singapore. He is also an elected member of the World Council of Biomechanics. He currently sits on the editorial boards of more than 14 international journals. Prof Lim has co-founded one incubator and five startups which are commercializing technologies developed in his lab.

He and his team have garnered more than 60 research awards and honors including the International Precision Medicine Conference Prize 2017, ASEAN Outstanding Engineering Achievement Award and Asian Scientists 100 in 2016, Vladimir K. Zworykin Award in 2015, University’s Outstanding Researcher Award and Outstanding Innovator Award in 2014, the Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) in 2012, President’s Technology Award in 2011 and the IES Prestigious Engineering Achievement Award in 2010 among others. His research was cited by the MIT Technology Review magazine as one of the top ten emerging technologies of 2006 that will “have a significant impact on business, medicine or culture.”

BEng (First Class Honors) (NUS), PhD (Cambridge)

Research Interests
Mechanobiology of human diseases; Microfluidic technologies for disease detection and diagnosis; Flexible wearable technologies
Link: http://www.bioeng.nus.edu.sg/nanolab/

Selected Publications
1. Warkiani, M E, B L Khoo, L Wu, A Tay, A A S Bhagat, J Han, C T Lim, Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics, Nature Protocols, 14, 1, 128-37, 2016.

2. Khoo, B L, G Grenci, T Y Jing, Y B Lim, S C Lee, J P Thiery, J Han, C T Lim, Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment. Science Advances, 2, 7, e1600274, 2016.

3. Yeo, J C, H K Yap, X Wang, Z Wang, C H Yeow*, C T Lim*, Flexible and stretchable strain sensing actuator for wearable soft robotics application, Advanced Materials Technologies, 1, 3, 2016.

4. Yeo, T, S J Tan, C L Chew, D P X Lau Xi, Y W Chua, S K Sai, I Gopal, G S Tan, T K H Lim, Daniel S W Tan, W T Lim, C T Lim, Microfluidic enrichment for the single cell analysis of circulating tumor cells, Scientific Reports, 6, 22076, 2016.

5. Wang, J, C-J Zhang, W N Chia, C C Y Loh, Z Li, Y M Lee, Y He, L-X Yuan, T K Lim, M Liu, C X Liew, Y Q Lee, J Zhang, N Lu, C T Lim, Z-C Hua, B Liu, H-M Shen, K S W Tan, Q S Lin, Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nature Communications, 6, 10111, 2015.

6. Gupta, M, B R Sarangi, J Deschamps, Y Nematbakhsh, A Callan-Jones, F Margadant, R-M Mege, C T Lim, R Voituriez, B Ladoux, Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing, Nature Communications, 6, 7525, 2015.

7.Vedula, S R K, G Peyret, I Cheddadi, T Chen, A Brugués, H Hirata, H Lopez-Menendez, Y Toyama, L Almeida, X Trepat, C T Lim*, B Ladoux*, Mechanics of epithelial closure over non-adherent environments, Nature Communications, 6, 6111, 2015.

8. Lee, W C, H Shi, Z Poon, L M Nyan, T Kaushik, G Shivashankar, J K Y Chan, C T Lim, J Han, K J Van Vliet, Multivariate biophysical markers predictive of mesenchymal stromal cell multi potency, PNAS, 111(42):E4409-18, 2014.

9. Yao, M, W Qiu, R Liu, A Efremov, P Cong, R Seddiki, M Payre, C T Lim, B Ladoux, R M Mège, J Yan, Force-dependent conformational switch of a-catenin controls vinculin binding, Nature Communications, 5, 4525, 2014.

10. Lim, C T, S B Hoon, Circulating tumor cells: Cancer's deadly couriers, Physics Today, 67, 2, 26-30, 2014.

11. Vedula, S.R.K., H. Hirata, M.H. Nai, A. Brugés, Y. Toyama, X. Trepat, C.T. Lim*, B. Ladoux*, Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 13, 87-96, 2014.

12. Hou H W, Warkiani M E, Khoo B L, Li Z R, Soo R A, Tan D S W, Lim W T, Han J Y, Bhagat A A S,
Lim C T, Isolation and retrieval of circulating tumor cells using centrifugal forces, Scientific Reports, 3, 1259, 2013.

13. Thiery, J P, C T Lim, Tumor dissemination: An EMT affair, Cancer Cell, 23, 3, 272-273, 2013.

14. Wang, Y T, S Y Chang, Y C Huang, T C Tsai, C M Chen, C T Lim, Nanomechanics insights into the performance of healthy and osteoporotic bones, Nano Letters, 13, 11, 5247-5254, 2013.

15. Vedula, S R K, M C Leong, T L Lai, P Hersen, A J Kabla, C T Lim*, B Ladoux* Emerging modes of collective cell migration induced by geometrical constraints, PNAS, 109, 32, 12974-12979, 2012. (F1000 recommended as being of special significance)

16. Wang, Y, C L Wong, K K Manga, P K Ang, J Lu, Y P Liu, C T Lim, K P Loh, Fluorinated Graphene for Promoting Neuro-Induction of Stem Cells, Advanced Materials, 31, 4285-4290, 2012. (selected for frontispiece)

17. Lee, W C, C H Y X Lim, H Shi, L A L Tang, Y Wang, C T Lim*, K P Loh*, The origin of enhanced stem cell growth and differentiation on graphene and graphene oxide, ACS Nano, 5, 9, 7334-7341, 2011.