Dr LIM Chwee Teck (林水德)

NUS Society (NUSS) Professor
Acting Director, Biomedical Institute for Global Health Research and Technoloigy (BIGHEART)
Principal Investigator, Mechanobiology Institute

National University of Singapore
9 Engineering Drive 1
Singapore 117575
Contact: +65-6516-7801

Homepage: http://www.bioeng.nus.edu.sg/people/pi/lmteck/default.html
Professor Lim is the inaugural NUS Society (NUSS) Professor, Acting Director of BIGHEART as well as founding Principal Investigator at the Mechanobiology Institute at NUS. He is also founding member of the Department of Biomedical Engineering, the university’s Nanoscience and Nanotechnology Initiative as well as the university’s Centre for Advanced 2D Materials. Prof Lim’s research interest are interdisciplinary and include mechanobiology of human diseases, microfluidic technologies for disease diagnosis and personalized medicine and flexible wearable technologies.

He has authored over 350 peer-reviewed papers and delivered more than 350 plenary/keynote/invited talks. He is an elected Fellow of the American Institute for Medical and Biological Engineering (AIMBE), International Academy of Medical and Biological Engineering (IAMBE) and the Academy of Engineering, Singapore. He is also an elected member of the World Council of Biomechanics. He currently sits on the editorial boards of more than 20 international journals. Prof Lim has co-founded one incubator and five startups which are commercializing technologies developed in his lab.

He and his team have garnered more than 70 research awards and honors including winner of IDTechEx Launchpad 2017, International Precision Medicine Conference Prize 2017, ASEAN Outstanding Engineering Achievement Award and Asian Scientists 100 in 2016, Vladimir K. Zworykin Award in 2015, University’s Outstanding Researcher Award and Outstanding Innovator Award in 2014, the Credit Suisse Technopreneur of the Year Award, Wall Street Journal Asian Innovation Award (Gold) in 2012, President’s Technology Award in 2011 and the IES Prestigious Engineering Achievement Award in 2010 and 2016 among others. His research was cited by the MIT Technology Review magazine as one of the top ten emerging technologies of 2006 that will “have a significant impact on business, medicine or culture.”

BEng (First Class Honors) (NUS), PhD (Cambridge)

Research Interests
Mechanobiology of human diseases; Microfluidic technologies for disease diagnosis and personalized medicine; 2D materials for biomedical applications; Flexible wearable technologies
Link: http://www.bioeng.nus.edu.sg/nanolab/

Selected Publications
1. Khoo, B L et al, Expansion of patient-derived circulating tumor cells from liquid biopsies using a CTC microfluidic culture device, Nature Protocols, 3, 34–58, 2018.

2. Kenry et al, When stem cells meet graphene: Opportunities and challenges in regenerative medicine, Biomaterials, 155, 236-250, 2018.

3. Lim, S B et al, An extracellular matrix-related prognostic and predictive indicator for early-stage non-small cell lung cancer, Nature Communications, 8, 1734, 2017.

4. Xi, W et al., Soft tubular microfluidics for 2D and 3D applications, PNAS, 114, 40, 10590–10595, 2017.

5. Saw, T B et al, Topological defects in epithelia govern cell death and extrusion, Nature, 544, 212-216, 2017.

6. Warkiani, M E, et al, Ultra-fast, label-free isolation of circulating tumor cells from blood using spiral microfluidics, Nature Protocols, 14, 1, 128-37, 2016.

7. Khoo, B L et al, Liquid biopsy and therapeutic response: Circulating tumor cell cultures for evaluation of anticancer treatment. Science Advances, 2, 7, e1600274, 2016.

8. Yeo, J C et al, Flexible and stretchable strain sensing actuator for wearable soft robotics application, Advanced Materials Technologies, 1, 3, 2016.

9. Yeo, T et al, Microfluidic enrichment for the single cell analysis of circulating tumor cells, Scientific Reports, 6, 22076, 2016.

10. Wang, J et al, Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum, Nature Communications, 6, 10111, 2015.

11. Gupta, M et al, Adaptive rheology and ordering of cell cytoskeleton govern matrix rigidity sensing, Nature Communications, 6, 7525, 2015.

12. Vedula, S R K et al, Mechanics of epithelial closure over non-adherent environments, Nature Communications, 6, 6111, 2015.

13. Lee, W C et al, Multivariate biophysical markers predictive of mesenchymal stromal cell multi potency, PNAS, 111, 42, E4409-18, 2014.

14. Yao, M et al, Force-dependent conformational switch of a-catenin controls vinculin binding, Nature Communications, 5, 4525, 2014.

15. Vedula, S R K et al, Epithelial bridges maintain tissue integrity during collective cell migration, Nature Materials, 13, 87-96, 2014.

16. Hou H W et al, Isolation and retrieval of circulating tumor cells using centrifugal forces, Scientific Reports, 3, 1259, 2013.

17. Thiery, J P, C T Lim, Tumor dissemination: An EMT affair, Cancer Cell, 23, 3, 272-273, 2013.

18. Vedula, S R K et al, Emerging modes of collective cell migration induced by geometrical constraints, PNAS, 109, 32, 12974-12979, 2012. (F1000 recommended as being of special significance)

19. Wang, Y et al, Fluorinated Graphene for Promoting Neuro-Induction of Stem Cells, Advanced Materials, 31, 4285-4290, 2012.

20. Lee, W C et al, The origin of enhanced stem cell growth and differentiation on graphene and graphene oxide, ACS Nano, 5, 9, 7334-7341, 2011.